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Nonoperative Management of Mismatch Repair–Deficient Tumors
Posted: 05/27/2025 | By: Chase Doyle

Neoadjuvant checkpoint blockade was previously shown to eliminate the need for surgery in a high proportion of patients with mismatch repair–deficient (dMMR), locally advanced rectal cancer. A study published in the The New England Journal of Medicine investigated whether this approach can be extended to all early-stage dMMR solid tumors, regardless of tumor site.

Question 1 of 5

What was the primary endpoint assessed in cohort 1 of the phase II study?

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